Prokinet

Domperidone
10 mg Tablet & 5 mg/5 ml Suspension
Description:

Prokinet(Domperidone) is a dopamine receptor antagonist. It gives gastroprokinetic action by blocking dopamine receptors located in the chemoreceptor trigger zone (CTZ) and stomach. Due to its weak penetration across the blood-brain barrier, it has almost no effect on the dopaminergic receptors in the brain, therefore excluding psychotropic and neurologic side effects.


  • Composition

    Prokinet Tablet : Each film coated tablet contains Domperidone Maleate BP equivalent to Domperidone 10 mg.

    Prokinet Suspension : Each 5 ml suspension contains Domperidone BP 5 mg.

  • Indication

    It is used in the following indications:
    1. Stimulation of gut motility in non-ulcer dyspepsia, gastro-esophageal reflux disease, reflux esophagitis, diabetic gastroparesis & functional dyspepsia.
    2. Speeding barium transit in follow through radiological studies.
    3. Prevention and symptomatic relief of acute nausea and vomiting due to cytotoxic therapy, anti-parkinsonism therapy, radio therapy or migraine.

  • Dosage & Administration

    Adults : 10 - 20 mg every 4 - 8 hours daily.

    Children : 0.2 - 0.4 mg/kg every 4 - 8 hours daily. For acute nausea and vomiting, maximum period of treatment is 12 weeks. It should be taken 15 - 30 minutes before a meal.

  • Contraindication

    It is contraindicated in patients with known hypersensitivity to Domperidone or any components of the preparation. Domperidone should not be used whenever gastro-intestinal stimulation might be dangerous (i.e., gastro-intestinal hemorrhage, mechanical obstruction or perforation). It is also contraindicated in prolactinoma.
  • Precaution

    It should be used with absolute caution in case of children because there may be increased risk of extra-pyramidal reactions. Since Domperidone is highly metabolized in liver, it should be used with caution in patient with hepatic impairment.
  • Side Effects

    It may produce hyperprolactinemia (1.3%). This may result in galactorrhea, breast enlargement & soreness and reduced libido. Dry mouth (1.9%), thirst, headache (1.2%), nervousness, drowsiness (0.4%), diarrhea (0.2%), skin rash and itching (0.1%) may occur during treatment with Domperidone. Extra-pyramidal reactions are seen in 0.05% of patients in clinical studies.
  • Drug Interaction

    The action of Domperidone on gastro-intestinal function may be antagonized by antimuscarinics and opoid analgesics. Care should be exercised when Domperidone is administered in combination with MAO (monoamine oxidase) inhibitors.
  • Overdose

  • Pregnancy & Lactation

    The safety of use of Domperidone has not been proven duing pregnancy; it is therefore not recommended during pregnancy. Animal studies have not demonstrated teratogenic effects on the fetus. Domperidone may precipitate galactorrhea and improve post-natal lactation. It is secreted in breast milk in very small quantities which is insufficient to be considered harmful.
  • Storage Condition

    Keep in a dry place away from light and heat. Keep out of the reach of children.
  • How Supplied

    Prokinet Tablet : Each box contains 100 tablets in Alu-PVC blister pack.

    Prokinet Suspension : Each amber PET bottle contains 60 ml suspension.