Nipoxen

Naproxen
250 mg Tablet & 500 mg SR Tablet
Description:

Nipoxen(Naproxen) is a non steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic & antipyretic properties. It is rapidly absorbed from the gastrointestinal tract and achieves 95% bioavailability.


  • Composition

    Nipoxen 250 Tablet : Each tablet contains Naproxen BP 250 mg.

    Nipoxen 500 SR Tablet : Each sustained release tablet contains Naproxen BP 500 mg.
  • Indication

    Nipoxen (Naproxen) is indicated for the relief of sign and symptoms of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, juvenile arthritis, tendonitis, bursitis & acute gout. It is also indicated for the management of primary dysmenorrhea & pain.
  • Dosage & Administration

    Rheumatoid arthritis, osteoarthritis and ankylosing spondylitis : The usual dose is 500-1000 mg daily in two divided doses after meals.

    Management of pain, primary dysmenorrhea, acute tendonitis & bursitis : Recommended starting dose is 500 mg followed by 500 mg every 12 hours or 250 mg every 6-8 hours. The initial total daily dose should not exceed 1250 mg and thereafter, the total daily dose should not exceed 1000 mg.

    Acute gout : Recommended starting dose is 750 mg followed by 250 mg every 8 hours until the attack has subsided.

  • Contraindication

    Nipoxen is contraindicated in patients with known hypersensitivity to Naproxen. It should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. It is contraindicated for the treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery.
  • Precaution

    Nipoxen is contraindicated in patients with known hypersensitivity to Naproxen. It should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. It is contraindicated for the treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery.
  • Side Effects

    Most frequently reported side effects include following :
    Gastrointestinal : Heartburn, abdominal pain, nausea, diarrhea, dyspepsia.
    Central Nervous System :Headache, vertigo, drowsiness.
    Dermatological :Pruritus (itching), purpura.
    Cardiovascular : Edema, palpitation.
    Others : Visual disturbances, hearing disturbances.
  • Drug Interaction

    ACE inhibitors : diminish the antihypertensive effect of ACE inhibitors.

    Antacids & Sucralfate : delay the absorption of Naproxen.

    Aspirin : increase adverse effects.

    Diuretics : reduce the natriuretic effect of Furosemide and Thiazides.

    Methotrexate : enhance the toxicity of Methotrexate.

    Warfarin : increase the risk of GI bleeding.

    Selective Serotonin Reuptake Inhibitors (SSRI) : increase the risk of GI bleeding.

  • Overdose

  • Pregnancy & Lactation

    US FDA pregnancy category of Naproxen is C. So, Naproxen should be avoided in pregnancy & lactation unless the potential benefits to the other outweigh the possible risks to the fetus.
  • Storage Condition

    Keep in a dry place away from light & heat. Keep out of the reach of children.
  • How Supplied

    Nipoxen Tablet : Each box contains 50 tablets in Alu-PVC blister pack.

    Nipoxen 500 SR Tablet : Each box contains 30 tablets in Alu-PVC blister pack.