Doxiva

Doxophylline
200 mg, 400 mg Tablet & 100 mg/5 ml Syrup
Description:

Doxiva (Doxophylline) is a novel bronchodilator. It structurally differs from Theophylline due to the presence of a dioxolane group in position 7. Doxophylline selectively inhibits phosphodiesterase-4 thereby relaxes bronchial smooth muscle. However, differently from Theophylline, Doxophylline appears to have decreased affinities toward adenosine A1 and A2 receptors, which may account for the better safety profile of the drug. Doxophylline is reported to inhibit platelet activating factor (PAF) and generation of leukotriene production.


  • Composition

    Doxiva 200 Tablet: Each film coated tablet contains Doxophylline INN 200 mg.

    Doxiva 400 Tablet: Each film coated tablet contains Doxophylline INN 400 mg.

    Doxiva Syrup: Each 5 ml syrup contains Doxophylline INN 100 mg.


  • Indication

    Doxiva (Doxophylline) is used to treat asthma, COPD and bronchospasm.
  • Dosage & Administration

    Adults : 1 tablet daily in the evening. On the basis of clinical response the dose may be increased to 1 tablet twice daily.

    Children (above 6 years of age) : 6 mg/kg twice daily.
  • Contraindication

    Doxophylline is contraindicated in acute myocardial infarction. It is also contraindicated in patients with hypotension, in lactating women & patients who have shown hypersensitivity to its components
  • Precaution

    The half-life of xanthine derivatives is influenced by a number of known variables. It may be prolonged in patients with liver disease, in patients with congestive heart failure and in those patients taking certain other drugs like erythromycin, troleandomycin, lincomycin, allopurinol, cimetidine, propanolol and anti-flu vaccine. In these cases, a lower dose of Doxophylline may be needed. Phenytoin, other anticonvulsants and smoking may cause an increase in clearance with a shorter mean half-life. In these cases higher doses of Doxophylline may be needed.
  • Side Effects

    Doxophylline rarely causes serious side effects, however possible side effect are similar for taking excess amount of caffeine. These include: nausea, vomiting, headaches, upset stomach and heartburn.
  • Drug Interaction

    Doxiva (Doxophylline) is used to treat asthma, COPD and bronchospasm.
  • Overdose

  • Pregnancy & Lactation

    Animal reproduction studies indicate that, Doxophylline does not cause fetal harm when administered to pregnant animals or can not affect reproduction capacity. However, since there is limited experience in human during pregnancy, xanthines should be given to pregnant women only if clearly needed. Doxophylline is contraindicated in nursing mothers.
  • Storage Condition

    Keep in a dry place away from light and heat. Keep out of the reach of children.
  • How Supplied

    Doxiva 200 Tablet: Each box contains 50’s tablets in Alu-PVDC blister pack.
    Doxiva 400 Tablet: Each box contains 30’s tablets in Alu-PVDC blister pack.
    Doxiva Syrup: Each Amber PET bottle contains 100 ml syrup.